Many Nephrotic Syndrome patients are confused why they are diagnosed with Nephrotic Syndrome, because they think they are healthy and there is no possibility for them to get Nephrotic Syndrome.
Then what causes Nephrotic Syndrome? Some explanations are as follows.
First, we should know what is Renal Glomeruli. Glomeruli refers to tiny blood vessels that filter wastes and excess water from the blood and send them to the bladder as urine. When damages caused on Kidneys’ glomeruli, Nephrotic Syndrome will occur.
When the glomeruli are working properly, they keep protein in the blood from leaking into the urine. Healthy kidneys allow less than 1 gram of protein to escape through the urine in a day. In nephrotic syndrome, the damaged glomeruli allow 3 grams or more of protein to leak into the urine during a 24-hour period.
As the result of this, protein loss, the blood is deficient. Normal amounts of blood protein are needed to help regulate fluid throughout the body. Protein acts like a sponge to soak up fluid into the bloodstream. When blood is low in protein, fluid accumulates in the body’s tissues rather than circulating. The fluid causes swelling and puffiness.
Nephrotic syndrome can occur with many diseases. In adults, the most common causes are diabetic nephropathy and membranous nephropathy. In older adults, the most common cause is amyloidosis. Prevention of nephrotic syndrome relies on controlling these diseases. However, the cause of nephrotic syndrome is unknown.
2014年1月25日星期六
What are the Causes of Nephrotic Syndrome
For people with Nephrotic Syndrome, they release massive protein in urine and form proteinuria. Proteinuria is the dominant symptom of Nephrotic Syndrome and it can cause edema, hypoalbuminemia and hyperlipidemia directly.
Protein is the essential nutrition of our body and can be divided into different types. Kidneys are responsible for filtering blood and when protein flow into kidney with blood, glomerular filtration membrane perform function to protect them from being leaked. Therefore, in normal cases, no protein be detected out in urine.
However, for people with Nephrotic Syndrome, their filtration membrane is damaged and protein can pass through casually. When protein flow through membrane and flow out of our body with urine, proteinuria is formed. Without timely and effective control, more and more protein leak out, as a result of which, protein content in blood decreases. Hypoalbuminemia refers to the illness condition where levels of albumin in blood serum are abnormally low.
Besides, because of great loss of protein in urine, plasma osmotic pressure decreases. Under such a conditon, fluid in blood ooze and into surrounding tissues. Edema is caused when there is an abnormal accumulation of fluid in the interstitium.
Hyperlipidemia means high lipid level in blood and it also can be caused by serious loss of protein from urine. We know protein is the irreplaceable nutrition of our body. When large amounts of protein are lost from urine, our liver will produce some protein to meet our physical demand. When liver synthetizes protein, lipid is produced at the same time. For Nephrotic Syndrome patients, because of severe shortage of protein, their liver has to work continuously to produce protein. When this condition lasts for a long time, lipid content in blood increases and hyperlipidemia is caused.
Protein is the essential nutrition of our body and can be divided into different types. Kidneys are responsible for filtering blood and when protein flow into kidney with blood, glomerular filtration membrane perform function to protect them from being leaked. Therefore, in normal cases, no protein be detected out in urine.
However, for people with Nephrotic Syndrome, their filtration membrane is damaged and protein can pass through casually. When protein flow through membrane and flow out of our body with urine, proteinuria is formed. Without timely and effective control, more and more protein leak out, as a result of which, protein content in blood decreases. Hypoalbuminemia refers to the illness condition where levels of albumin in blood serum are abnormally low.
Besides, because of great loss of protein in urine, plasma osmotic pressure decreases. Under such a conditon, fluid in blood ooze and into surrounding tissues. Edema is caused when there is an abnormal accumulation of fluid in the interstitium.
Hyperlipidemia means high lipid level in blood and it also can be caused by serious loss of protein from urine. We know protein is the irreplaceable nutrition of our body. When large amounts of protein are lost from urine, our liver will produce some protein to meet our physical demand. When liver synthetizes protein, lipid is produced at the same time. For Nephrotic Syndrome patients, because of severe shortage of protein, their liver has to work continuously to produce protein. When this condition lasts for a long time, lipid content in blood increases and hyperlipidemia is caused.
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