Risk Factors that may Lead to Uremia

1.Chronic glomerulonephritis

For those patients who have been diagnosed with chronic glomerulonephritis, their kidney condition tends to aggravate at a higher rate if they have persistent proteinuria or their blood pressure is poorly controlled.

Also, the prognosis of the disease is also affected by the pathological classification and pathological stages. Some types of nephritis, such as MCD, light mesangial proliferation, would have good prognosis, while some types of nephritis, like mesangioproliferative glomerulonephritis, RPGN(rapidly progressive glomerulonephritis), would pose unfavorable prognosis. In some cases, patients would progress into uremia in a few months or weeks after the first attack.

2.Diabetic nephropathy

Once patients with diabetic nephropathy present clinical proteinuria, their kidney function would decline progressively. And almost one fourth of the patients with diabetic nephropathy would develop into uremia within six years once they present persistent proteinuria.

3.Hypertensive nephropathy

Patients with long-time medical history of hypertension and a poor control of their blood pressure would develop renal insufficiency apart from cardio-vascular diseases.

In addition, patients who had medical history of hypertensive crisis tend to develop damage to kidneys.

4.Bilateral hydronephrosis

Patients with bilateral hydronephrosis caused by kidney stones or other diseases would present bilateral hydronephrosis. If the obstruction could not lifted timely, kidney function would deteriorate in the long run, leading to uremia eventually.

5.Nephrotoxic medicines

Long-term intake of nephrotoxic medicines, such as certain antiobitics, pain-killers and chemotherapeutic drugs can also cause renal failure.