What are the Complications of Nephrotic Syndrome

1.Infection

A large number of immune globulin from urine loss, plasma protein reduced, affecting antibody formation. Adrenal cortex hormones and the application of cytotoxic drugs, in which patients resistant to systemic decline in vulnerable to infection, such as skin infections, primary peritonitis, respiratory tract infections, urinary tract infection, or even induced sepsis.

2.Thrombosis

thrombosis prone patients with nephrotic syndrome, particularly in the incidence of membranous nephropathy up to 25% ~ 40%. The reasons for the formation of thrombus edema, the patient′s less venous stasis, high blood lipids, blood concentration to viscosity increase, high fibrinogen levels, and v, Ⅶ, Ⅷ, x factor increases and the use of adrenal cortex hormones and the blood-prone hypercoagulable state and so on.

3.Coronary heart disease

nephrotic syndrome patients often have hyperlipidemia and hypercoagulability, so prone to coronary heart disease. It was reported that patients with nephrotic syndrome, the incidence of myocardial infarction 8 times higher than normal. Nephrotic syndrome with coronary heart disease has become the cause of death of the third factor (after infection and renal failure).

4.Acute renal failure

patients with nephrotic syndrome due to massive proteinuria, hypoalbuminemia, hyperlipidemia, often in a low blood volume and in vivo hypercoagulability. District vomiting, diarrhea, use of antihypertensive drugs and , when a large number of diuretic diuretic, may make a sudden decrease in renal blood perfusion and thus make lower glomerular filtration rate, leading to acute renal failure. In addition, nephrotic syndrome and renal interstitial edema, and protein concentration blocked the formation of tubular casts and other factors can also be induced acute renal failure.

5.Electrolyte and metabolic disorders

repeated use of diuretics or long-term ban on unreasonable salt can enable patients with nephrotic syndrome secondary to hyponatremia; the use of adrenal cortex hormones and a large number of diuretics result in a large number of urination, if not timely fill potassium, prone to hypokalemia.