Hemolytic Uremia Syndrome mainly manifested as microangiopathic hemolysis, thrombocytopenia and acute renal failure; if accompanied with nervous system symptoms and noninfectious fever, it will be thrombotic thrombocytopenic purpura. Therefore, Hemolytic uremia syndrome and thrombotic thrombocytopenic purpura are similar in clinical manifestation and causes, and they both belong to thrombotic microangiopathy.
The causes of hemolytic uremia syndrome are still not very clear, and it may have relation with infection , inheritance and other factors. These factors lead to endothelial cells damage and broke negative charge brought by endothelial cells under physiology condition, decrease PGI2 and increase platelet adhesiveness; operated endothelial cells start blood clotting of white cells and plasma proteins, bring thrombopoiesis to happen, thus lots of blood cells are consumed and result in bleeding; hemolytic anemia will occur when red cells flow through vessels that is formed by microthrombus. Microembolization mostly occur in kidney, which may result in acute renal failure.
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